Preparation and Characterization of pH- and Temperature-responsive by Different Composition Chitosan-P(MAA-co-NIPAM) Hydrogel for Drug Delivery System / S. Z. M. Rasib ...[et al.]

S. Z., M. Rasib and N. F., Muhamad and H, M. Akil and Z. A., A. Hamid (2017) Preparation and Characterization of pH- and Temperature-responsive by Different Composition Chitosan-P(MAA-co-NIPAM) Hydrogel for Drug Delivery System / S. Z. M. Rasib ...[et al.]. Journal of Mechanical Engineering (JMechE), SI 4 (2). pp. 123-133. ISSN 18235514

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Abstract

In this paper, (chitosan-poly(methacrylic acid-co-N-isopropylacrylamide)) [Chitosan-P(MAA-co-NIPAM)], a multi-responsive hydrogel was successfully fabricated by free-radical polymerization in aqueous media. Chitosan was crosslinked with P(MAA-co-NIPAM) network as a suggestion to improve the efficiency of chitosan as a drug carrier. Due to the hydrophilic and hydrophobic characteristics of MAA and NIPAM monomers presented in the network, the swelling behaviour at different pH and temperature was investigated in this paper. The composition, morphological stability, swelling behavior at various pH and temperature environment of the Chitosan-P(MAA-co-NIPAM) hydrogel were studied using Fourier transform infra-red (FT-IR), Field Emission Scanning Electron Microscopy (FESEM) and swelling test by weight ratio of the hydrogel. This study found that additional feed of MAA and NIPAM monomers during polymerization increased the amount of PMAA and PNIPAM crosslinked in the hydrogel. As a result, the value of LCST increased from 32℃ to more than 37℃. The swelling ratio of the hydrogel was found to be maximum at pH 7 which is suitable to be used in body system especially in human blood of pH 7.4. Thus, the role of Chitosan-P(MAA-co-NIPAM) as a carrier of a drug in drug delivery system has been approved.

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Item Type: Article
Creators:
Creators
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S. Z., M. Rasib
UNSPECIFIED
N. F., Muhamad
UNSPECIFIED
H, M. Akil
UNSPECIFIED
Z. A., A. Hamid
UNSPECIFIED
Subjects: T Technology > TJ Mechanical engineering and machinery > Energy conservation
T Technology > TJ Mechanical engineering and machinery > Mechanics applied to machinery. Dynamics
T Technology > TJ Mechanical engineering and machinery > Heat engines
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Mechanical Engineering
Journal or Publication Title: Journal of Mechanical Engineering (JMechE)
UiTM Journal Collections: UiTM Journal > Journal of Mechanical Engineering (JMechE)
ISSN: 18235514
Volume: SI 4
Number: 2
Page Range: pp. 123-133
Item ID: 39037
Uncontrolled Keywords: Hydrogel; Chitosan; pH-Responsive; Temperature-Responsive; Drug Delivery.
URI: https://ir.uitm.edu.my/id/eprint/39037

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39037

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