The permeability of acetaminophen loaded chitosan film for transdermal drug delivery

Chitosan, a natural derivative of chitin serves as multipurpose polymer and shows mucoadhesion and permeation enhancement properties for both oral and transdermal drug delivery systems. This study clearly confirmed that the selection of suitable concentration of chitosan do alter the drug permeation profile. The percentage of cumulative drug permeation was found to be 1.82±0.17%, 6.10±1.11% and 0.72±0.37% for the formulations 2, 3 and 4% w/w of chitosan concentration respectively. Chitosan with 3% w/w concentration showed the highest drug permeation profile at 6.10± 1.11 % after 24 hours in contrast to other formulations of 2 and 4% w/w. In conclusion, chitosan is potentially suitable for use as a transdermal film carrying acetaminophen, p< 0.05.