Morphological and histological analysis of ovary and uterus following treatment with delta­ tocotrienol in nicotine-treated mice

Vitamin E is one of the vitamins that is soluble in the fat. It has been discovered in 1922 and since then a lot of studies had been conducted to see its effects to the human body especially its anti-oxidant effects. This study is conducted to determine the effects of tocotrienol on the structural damaged causes by nicotine. The mice been divided into 5 groups and each group contain 6 mice and underwent different treatments. For group A, the mice have been treated with 0.1 ml of 0.9 % of normal saline, group B treated with 0.1 ml com oil, group C been treated with 3mg/kg/day of nicotine, group D been treated with 60mg/kg/day of delta-tocotrienol and group E treated concurrently with 60mg/kg/day of delta-tocotrienol and 3mg/kg/day of nicotine. Form the result obtained, it clearly seen that administration of delta-tocotrienol is able to reverse the damage on ovaries structure causes by the nicotine. However the effect of administration of delta-tocotrienol in reversing the damage causes by the nicotine on uterus is unclear.