Effects of sugar alcohols as water activity reducing agents on secondary metabolites of polar fungi

This dissertation investigates the effects of sugar alcohols either alone or in combinations on secondary metabolite productions of polar fungi. Those sugar alcohol solutions which are Glycerol, Xylitol, Sorbitol, and Erythritol that have an ability to reduce water activity were chose due to non-toxic property and commonly used in food manufacturing process. 24 combinations of sugar alcohol with different concentrations which are 3%, 10%, 15% as low, medium and high respectively were prepared in MTP to study their effects on secondary metabolite productions of E4SB, E 1 LB, E 1 PB and E6P A. The height of peaks which indicate the secondary metabolite productions level as well as the existence of additional secondary metabolites productions were analysed from chromatograms obtained. Most of the sugar alcohol combinations tend to cause reduction of secondary metabolite productions level of cultured fungi as compared to control except Xylitol at low concentration.