Amplification of whole mRNA in small airways epithelial cell by template switcing method / Muhd Badrulhisham Sulaini

The small airways epithelial cells are vital part of the lung that are positioned at the interface between conducting airways and alveoli (Lilly et al., 1997). In the airways, they orderly aligned forming a continuous lining as protection or barrier against exogenous agents which can be lethal to the lung that are mainly result of inhaled substance for instance particulate pollutant and also pathogens (Picot, 2005). Providing sustain conduit for air from and also to the alveoli, site where diffusion or gases exchange occur is another role plays by this cell. Generally, small airways epithelial cell is made up of cuboidal and columnar type of cell. This cell is one of the major determinant and predominant area of interest for researchers in patient having diseases which are related or closely related to lung such as bronchiolitis obliterans and chronic obstructive pulmonary disease as a comparison to normal small airways epithelium (Crystal et al., 2008).