Effects of co-cultivation of HAB10R12 with other microorganisms on their secondary metabolites production / Noor Nadia Mat Nor

Co-cultivation of fungi means cultivation of two different fungi on the same medium. In this study, many different types of fungi had been co­ cultivated together in order to determine whether this kind of method could be used to produce unique secondary metabolites that could have importance in the pharmaceutical industry. Previously, it was unknown whether competition has any effects on the production of secondary metabolites. In this study, the fungi were co-cultivated together and they were incubated for 2 weeks and 4 weeks. The co-cultivated fungi were then being extracted and the extract were analyzed by HPLC. The extracts produced were also used in biological activity test against E.coli and Candida albicans. From the result obtained, there were a few of new peaks obtained in HPLC and there were two distinct extracts which had activity against E.coli. These findings indicate that the co-cultivation pf the fungi could be a very promising method for inducing novel secondary metabolites.