Effects of estrous cycle on vascular contractility in the presence and absence of endothelium / Nurul Hananni Abdul Latif

The aim of this study was to determine the possible influence of sex hormones on the contractile responses induced by phenylephrine and angiotensin II, in endothelium intact and denuded tissues. For this purpose, thoracic aorta segments from female WKY rats were used. Endothelium denuded aorta exhibited higher sensitivity to phenylephrine and angiotensin II contractility compared to endothelium intact tissues as tissue denudation remove endothelium which inhibit contractile agonist. States of estrous cycle modulated phenylephrine induced contractile responses more in endothelium intact tissues compared to angiotensin II and equally regulated responses for phenyelephrine and angiotensin II in endothelium denuded tissues.