Investigation on EMF during solubilisation of griseofulvin / Siti Rohaiza Md Saad

Md Saad, Siti Rohaiza (2008) Investigation on EMF during solubilisation of griseofulvin / Siti Rohaiza Md Saad. Degree thesis, Universiti Teknologi MARA (Kampus Puncak Alam).

Abstract

Solubility is an essential physicochemical property that has to be evaluated during the drug discovery and development process. Our study of interest is to investigate the pattern of electromotive force changes during solubilisation of aqueous insoluble drug, Griseofulvin in the presence of solubility enhancer. The solubility measurements were done by using UV-visible spectroscopy, whereas the emf and pH was analysed by using Automatic Potentiometric Titrator. The experimental data of the solubility study of Griseofulvin in presence of the three different agents (PEG 1500, PEG 4000, PEG 6000) showed varied response in regard to solubility enhancements. It was observed that higher solubility enhancement will correspond to lower value of emf.

Metadata

Item Type:	Thesis (Degree)
Creators:	Creators Email / ID Num. Md Saad, Siti Rohaiza UNSPECIFIED
Contributors:	Contribution Name Email / ID Num. Thesis advisor Tripathy, Minaketan UNSPECIFIED
Subjects:	R Medicine > RS Pharmacy and materia medica > Materia medica > Pharmaceutical dosage forms R Medicine > RS Pharmacy and materia medica > Materia medica > Pharmaceutical chemistry
Divisions:	Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Pharmacy
Programme:	Bachelor of Pharmacy
Keywords:	EMF, solubilisation, griseofulvin
Date:	2008
URI:	https://ir.uitm.edu.my/id/eprint/103993