Synthesis, characterization and antibacterial activity of Co (II), Cu (II) and Cd (II) transition metal complexes of nos tridentate schiff base derived from S-2-fluorobenzyldithiocarbazate and isatin / Nur Afida Idayu Kamaruddin

A new Schiff base was formed from the condensation reaction of S-2-fluorobenzyldithiocarbazate with isatin. Complexes of cobalt(II), copper(II) and cadmium(II) with Schiff base were successfully prepared. These compounds were characterized by elemental analysis and various physicochemical techniques. The analysis of IR data shows that the Schiff base was coordinated to the copper(II) and cadmium(II) ions as NS bidentate ligands whereas in cobalt(II) ion as NOS tridentate ligand. The Schiff base and its metal complexes were screened for antibacterial activity by using disc diffusion method. Antibacterial activity screening was carried out against Gram positive and Gram negative bacteria which are Bacillus subtilis and Pseudomonas aeruginosa. The metal complexes were found to be strongly active against these selected bacteria compared to Schiff base.