Synthesis of 1,4,7,10-tetraazacyclododecane (cyclen) compound for molecular study purposes / Hasryn Azzuar Mohd Khairy

The main objective of this study is to synthesize a macrocyclic compound, 1,4,7,10-tetra­ azacyclododecane ( cyclen). There are several techniques involved in order to synthesize this compound. Although in this experiment, only one method was choosen from several methods that are able to synthesize this compound. This experiment used Diethylenetriamine (DT) and Diethanolamine (DE) as starting material. The Diethylenetriamine and Diethanolamine are tosylated first by using para-toluene benzyl chloride or called Tosyl chloride (TsCl) with addition of triethylamine as a base and dichloromethane as a solvent. Diethylenetriamine preparation will yield N-Tosyl as a product and Diethanolamine will yield 0-Tosyl as a product. Both of these products then coupled to yield the compound called cyclen that are very useful for the molecular study purposes. The already-made cyclen product from the factory made or commercially is available, but it is quite expensive, so that this experiment done to produce cyclen by ownself for the further purposes. Thin Layer Chromatography (TLC) is used for all of the chemical analysis and identification.