Zubir, Nur Nadia
(2007)
Effects of phosphine ligands on heck reaction / Nur Nadia Zubir.
Degree thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
Abstract
The use of phosphine ligands in Pd-catalyzed Heck reactions between an aryl iodide and a styrene was investigated. One phosphine ligand is the P(o-Tol)3 and the other is a phosphine ligannd that has been precomplexed with Pd, forming the preformed catalyst, Pd(PPh3)4. Two reactions using these ligands ( one in each reaction) were made for the synthesis of 3,4-dimethoxy-12-benzyloxystilbene and the resulting reaction time and yield for the two reactions using two different ligands were compared. The reaction using P(o-Tol)3 took 22 hours and gave 9.83% yield while the preformed catalyst [Pd(PPh3)4] took 12 hours and gave 16.4% yield.
Metadata
| Item Type: | Thesis (Degree) |
|---|---|
| Creators: | Creators Email / ID Num. Zubir, Nur Nadia UNSPECIFIED |
| Contributors: | Contribution Name Email / ID Num. Thesis advisor Feroz, Fareeda UNSPECIFIED |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Pharmacy |
| Programme: | Bachelor of Pharmacy |
| Keywords: | Heck reaction, phosphine ligands, preformed catalyst |
| Date: | 2007 |
| URI: | https://ir.uitm.edu.my/id/eprint/99591 |
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