Effects of phosphine ligands on heck reaction / Nur Nadia Zubir

Zubir, Nur Nadia (2007) Effects of phosphine ligands on heck reaction / Nur Nadia Zubir. Degree thesis, Universiti Teknologi MARA (Kampus Puncak Alam).

Abstract

The use of phosphine ligands in Pd-catalyzed Heck reactions between an aryl iodide and a styrene was investigated. One phosphine ligand is the P(o-Tol)3 and the other is a phosphine ligannd that has been precomplexed with Pd, forming the preformed catalyst, Pd(PPh3)4. Two reactions using these ligands ( one in each reaction) were made for the synthesis of 3,4-dimethoxy-12-benzyloxystilbene and the resulting reaction time and yield for the two reactions using two different ligands were compared. The reaction using P(o-Tol)3 took 22 hours and gave 9.83% yield while the preformed catalyst [Pd(PPh3)4] took 12 hours and gave 16.4% yield.

Metadata

Item Type:	Thesis (Degree)
Creators:	Creators Email / ID Num. Zubir, Nur Nadia UNSPECIFIED
Contributors:	Contribution Name Email / ID Num. Thesis advisor Feroz, Fareeda UNSPECIFIED
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Divisions:	Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Pharmacy
Programme:	Bachelor of Pharmacy
Keywords:	Heck reaction, phosphine ligands, preformed catalyst
Date:	2007
URI:	https://ir.uitm.edu.my/id/eprint/99591