Influence of microwave on dissolution medium and its effects on sulphanilamide and sulphathiazole dissolution / Mardhiyah Kamal

The potential use of microwave irradiation as an approach for designing dissolution medium for poorly water soluble drugs was investigated. In order to make the drugs dissolve in the water, the microwave irradiation was used to modify the physicochemical properties of deionized water. Sulphanilamide and sulphathiazole were selected as the model poorly water soluble drugs. The deionized water was subjected to microwave irradiation at 80 W for 37.5 min and at 300 W for 10 min. The profiles of drug dissolution, drug solubility, media pH, temperature, conductivity and mobility were determined. In order to increase the dissolution rate of low aqueous solubility drugs, deionized water molecules were made more mobile through subjecting them to treatment by microwave irradiation. The energy absorbed by the water molecules can break the bond interaction between the molecules and thus make the water molecules more accessible to interact with poor water-soluble drug and aid to disperse and dissolve the drug molecules in the dissolution medium.