Effects of indigenous plant octomeles sumatrana on blood parameters in rats / Khamisah Itim

Octomeles sumatrana also known as 'Binuang" is one of the traditional medicines applied by the enormous Kadazandusun communities in Borneo. Primarily, it is used as tonic or to treat stomachache, bone pain and muscle sprain. The aim of this study is to determine the potential effects and toxicity associated with the use of Octomeles sumatrana on blood parameters. Two group of five rats were given either the extracts (treatment group) or normal saline (control group).The water soluble extracts of Octomeles sumatrana bark was administered by gavage with the use of oral needle. Later, the blood samples were obtained by cardiac puncture. No mortality was observed upon administration of OS for both acute and sub acute toxicity study. However, there are changes in the blood parameters when evaluated with the conventional pharmacologic method. The result obtained, revealed the differences between the control and the treatment group biochemical properties. In acute toxicity study, the level of lymphocyte, monocyte and total protein were statistically higher than the control group and there were falls in the level of AST. From sub acute toxicity study, the level of ALT, AST, cholesterol, urea and chloride were statistically lowered in the treatment group compare to the control group.