Solubilization of griseofulvin by mixture of sodium lauryl sulfate (sls) and polyoxyethylenesorbitan monooleate (tween 80) by using uv-visible spectrophotometer / Syazzana Dzulkifli

The use of mixed surfactant in solubilization of poorly soluble drug has been described in literature. The aim of this study was to determine the solubility of griseofulvin in mixed surfactant solutions compare to in single surfactant solutions. In this study also, the surface tension and critical micellar concentration (CMC) of surfactant solutions and surfactant solutions containing griseofulvin was determined. The relationship between CMC and drug solubility was also investigated in detail. Samples were prepared by dissolving relevant single surfactant at different concentration ranging from 0.005 to 0.12% w/v and mixed surfactant at different ratios ranging from 0.2 to 0.8 in distilled water at room temperature, 25 ± 0.2 °C and an amount of griseofulvin (0.1 %w/v) was dissolved in each concentrations and ratios. Surface tension of griseofulvin in single surfactant solution and mixed surfactant solution was determined by using a torsion balance with Du Nouy ring method. The CMC in single surfactant solutions and its mixture was obtained from the break of the surface tension-concentration profiles. The determination of griseofulvin concentration was done by using UV-Visible spectrophotometer. There was a solubility enhancement of griseofulvin observed in 60:40 molar fraction composition. The CMC value was also greatly reduced in 60:40 molar fraction composition. The solubility enhancement of griseofulvin in 60:40 molar fraction composition system was explained in terms of surfactant-surfactant interaction occurring within the solubilization site and the characteristics of mixed micelles itself.