Synthesis and antibacterial activity of 4'-methoxy-5, 7-dimethoxyflavanone & 2, 4-(4-butylphenyl)-5, 7-dimethoxychroman-4-one / Angellia Samantha Sibat

Plants are generally well-known for their benefits in becoming a natural resource to cure illnesses and diseases in human beings. Being secondry plant metabolites that are categorized as one of the largest classes, flavonoids can be effortlessly found in many different parts of the plants. The flavanoid has attracted massive attention for its involvement in antibacterial activities. Flavanone is well-known as the subclass of the flavonoid family and is also identified as dehydroflavones. It is one of the critical classes of flavonoids that can be widely found among citrus fruits. Hence, this study aims to synthesize 4’ methoxy-5. 7-dimethoxy flavanone and 2-(4-butylphenyl)-5, 7-dimethoxychroman-4-one through the Claisen-Schmidt condensation, as well as investigate its antibacterial activity. The compound later was characterized by using Gas Chromatography Mass Spectrometry (GC-MS), Fourier-Transform Infrared Spectroscopy (FTIR), and Nuclear Magnetic Resonance (NMR). This research scope will focus on the synthesize and characterization of flavanone, its antibacterial activity, and the synthesis of flavanones from the corresponding chalcones The MIC and MBC of the synthesis compounds were tested on Escherichia coli (EC), Pseudomonas aeruginosa (PA), Staphylococcus aureus (SA), and Streptococcus pyrogens (SP). It is found that by utilizing the methods of serial dilution method in order to determine the MIC and MBC. 4’-methoxy-5, 7-dimethoxyflavanone and 2-(4-butylphenyl)-5, 7-dimethoxychroman-7-one are unable to inhibit pathogenic bacterial.