In vitro wound healing potential and the identification of related bioactive compound(s) from rhodomyrtus tomentosa (aiton) hassk / Evana Kamarudin

Wounds and their treatment significantly strain the healthcare system in terms of cost, time, and energy expended. The productivity and quality of life setbacks are incalculable. Herbal remedies are widely used in complementary and alternative medicine worldwide. Rhodomyrtus tomentosa leaves or known as "Kemunting", which are traditionally claimed to treat wounds, have not been proven scientifically. This research aimed to elucidate the mechanism of action of rhodomyrtone, Fraction 5-ethylacetate (F5-EA) of R. tomentosa crude ethanolic extract (SERT) in enhancing the wound healing through Wnt/fi-catenin pathway. The first part of this study wasconducted to profile SERT, identify, and quantify rhodomyrtone in liquid-liquidextraction (LLE) Fractions 1 - 6 of the SERT by conducting liquid chromatography -mass spectrophotometry (LCMS). Free radical scavenging activity (DPPH) was used to assess the antioxidant activity of SERT and LLE Fractions 1-6.