Synthesis and characterization of benzoyl thiourea (thiosemicarbazone) derivative and its Fe (ii), Co (ii), and Cu (ii): potential candidates for antimicrobe / Gusti Nur Farwiza Gusti Anuar

Microbes are resistant to medicine and this has motivated researchers to develop new medicine from various chemical compounds, including thiosemicarbazone (TSC) derivatives and their metal complexes. In this study, two benzoyl thiourea containing thiosemicarbazones: N-(2-{[(Z)phenylmethylidene] carbamothioyl} hydrazinecarbothioyl) benzamide, L1 and N-(2-{[(1E,2E)-3-phenylprop-2-en-1-ylidene]carbamothioyl} hydrazinecarbothioyl)benzamide, L2, were synthesized via two steps starting by attaching benzoyl thiourea into hydrazine side followed by condensation reaction on the other side in between amine group and aromatic aldehyde groups. Both new compounds were experimentally characterized by spectral methods using IR and UV-Vis. All benzoyl thiourea and aromatic aldehydes were successfully attached to the thiosemicarbazone moiety. The presence of the C=O group appeared in FTIR around 1676.7 cm-1 and 1607.08 cm-1, respectively, indicating the attachment of benzoyl thiourea and aromatic aldehyde. Further complexation of these ligands with Fe (II), Co (II), and Cu (II) was characterized spectroscopically. The result shows that all the functional groups of the newly synthesized thiosemicarbazone ligands can coordinate with metals and shows a promising potency to act as an antimicrobial agent.