The new emerging of diabetes treatment: a review of oral insulin / Jihan Maftuuhatus Zuhra [et al.]

Zuhra, Jihan Maftuuhatus and Emad, Rand Omar and Kamarudin, Nur Ain Nabihah and Zulkifli, Nur Wahida (2023) The new emerging of diabetes treatment: a review of oral insulin / Jihan Maftuuhatus Zuhra [et al.]. International Journal of Pharmaceuticals, Nutraceuticals and Cosmetic Science (IJPNaCS), 6 (2). pp. 1-11. ISSN 2682-8146

Abstract

Diabetes patients typically get daily subcutaneous insulin injections; however, due to the discomfort of these injections, patient compliance is difficult to maintain; hence, several delivery methods, including oral administration, are being investigated. The emerging field of oral insulin administration is summarised in this overview. There are many formulations to develop oral insulin, such as PEGylation of insulin, targeting moieties-mediated transport strategy, cell penetrating peptides (cpps)-assisted permeation strategy, smart oral robotics-associated traverse strategy, hydrogels for insulin: microenvironment-responsive hydrogels, and zwitterionic micelles. Future oral insulin development will be resolved by non-erratic absorption and bioavailability. One method to deliver the therapeutic ingredient to the colon, improve insulin bioavailability, and eliminate small intestine absorption variation is to include compatible and appropriate excipients in an insulin tablet, such as an acid-resistant enteric coating, enzyme inhibitor, absorption enhancer, and mucoadhesive polymer.

Metadata

Item Type: Article
Creators:
Creators
Email / ID Num.
Zuhra, Jihan Maftuuhatus
UNSPECIFIED
Emad, Rand Omar
UNSPECIFIED
Kamarudin, Nur Ain Nabihah
UNSPECIFIED
Zulkifli, Nur Wahida
wahidazulkifli@uitm.edu.my
Subjects: R Medicine > RC Internal Medicine > Diabetes Mellitus
Divisions: Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Pharmacy
Journal or Publication Title: International Journal of Pharmaceuticals, Nutraceuticals and Cosmetic Science (IJPNaCS)
UiTM Journal Collections: UiTM Journal > International Journal of Pharmaceuticals, Nutraceuticals and Cosmetic Science (IJPNaCS)
ISSN: 2682-8146
Volume: 6
Number: 2
Page Range: pp. 1-11
Keywords: antidiabetics, diabetes mellitus, insulin, review
Date: 2023
URI: https://ir.uitm.edu.my/id/eprint/87282
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