Man, Farahdina
(2018)
Safety assessment and bioavailability study of Brucea javanica seeds aqueous extract / Farahdina Man.
Masters thesis, Universiti Teknologi MARA (UiTM).
Abstract
Diabetes mellitus is a disease that is increasing worldwide. The aqueous decoction of Brucea javanica (Simaroubaceae) seeds are traditionally used as anti-diabetic medicine. Standardization of an extract ensures the therapeutic effect is reproducible. The aim of the research is to evaluate the safety of daily consumption of a standardized aqueous extract and to develop of a sensitive Liquid Chromatographytandem Mass Spectrometry (LC-MS/MS) system to establish the bioavailability and pharmacokinetics study of bruceine D and E. A High Performance Liquid Chromatography-Photodiode Array (HPLC-PDA) method was developed and validated for the determination of both bruceines in the aqueous extract.
Item Details
| Item Type: | Thesis (Masters) |
|---|---|
| Creators: | Creators Email / ID Num. Man, Farahdina UNSPECIFIED |
| Contributors: | Contribution Name Email / ID Num. Thesis advisor Choo, Chee Yan UNSPECIFIED |
| Subjects: | R Medicine > R Medicine (General) > Medical education. Medical schools. Research R Medicine > RZ Other systems of medicine |
| Divisions: | Universiti Teknologi MARA, Shah Alam > Faculty of Pharmacy |
| Programme: | Master of Science |
| Keywords: | Brucea javanica, diabetes mellitus, anti-diabetic, |
| Date: | 2018 |
| URI: | https://ir.uitm.edu.my/id/eprint/84259 |
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