Safety assessment and bioavailability study of Brucea javanica seeds aqueous extract / Farahdina Man

Man, Farahdina (2018) Safety assessment and bioavailability study of Brucea javanica seeds aqueous extract / Farahdina Man. Masters thesis, Universiti Teknologi MARA (UiTM).

Abstract

Diabetes mellitus is a disease that is increasing worldwide. The aqueous decoction of Brucea javanica (Simaroubaceae) seeds are traditionally used as anti-diabetic medicine. Standardization of an extract ensures the therapeutic effect is reproducible. The aim of the research is to evaluate the safety of daily consumption of a standardized aqueous extract and to develop of a sensitive Liquid Chromatographytandem Mass Spectrometry (LC-MS/MS) system to establish the bioavailability and pharmacokinetics study of bruceine D and E. A High Performance Liquid Chromatography-Photodiode Array (HPLC-PDA) method was developed and validated for the determination of both bruceines in the aqueous extract.

Metadata

Item Type:	Thesis (Masters)
Creators:	Creators Email / ID Num. Man, Farahdina UNSPECIFIED
Contributors:	Contribution Name Email / ID Num. Thesis advisor Choo, Chee Yan UNSPECIFIED
Subjects:	R Medicine > R Medicine (General) > Medical education. Medical schools. Research R Medicine > RZ Other systems of medicine
Divisions:	Universiti Teknologi MARA, Shah Alam > Faculty of Pharmacy
Programme:	Master of Science
Keywords:	Brucea javanica, diabetes mellitus, anti-diabetic,
Date:	2018
URI:	https://ir.uitm.edu.my/id/eprint/84259