Safety assessment and bioavailability study of Brucea javanica seeds aqueous extract / Farahdina Man

Man, Farahdina (2018) Safety assessment and bioavailability study of Brucea javanica seeds aqueous extract / Farahdina Man. Masters thesis, Universiti Teknologi MARA (UiTM).

Abstract

Diabetes mellitus is a disease that is increasing worldwide. The aqueous decoction of Brucea javanica (Simaroubaceae) seeds are traditionally used as anti-diabetic medicine. Standardization of an extract ensures the therapeutic effect is reproducible. The aim of the research is to evaluate the safety of daily consumption of a standardized aqueous extract and to develop of a sensitive Liquid Chromatographytandem Mass Spectrometry (LC-MS/MS) system to establish the bioavailability and pharmacokinetics study of bruceine D and E. A High Performance Liquid Chromatography-Photodiode Array (HPLC-PDA) method was developed and validated for the determination of both bruceines in the aqueous extract.

Metadata

Item Type: Thesis (Masters)
Creators:
Creators
Email / ID Num.
Man, Farahdina
UNSPECIFIED
Contributors:
Contribution
Name
Email / ID Num.
Thesis advisor
Choo, Chee Yan
UNSPECIFIED
Subjects: R Medicine > R Medicine (General) > Medical education. Medical schools. Research
R Medicine > RZ Other systems of medicine
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Pharmacy
Programme: Master of Science
Keywords: Brucea javanica, diabetes mellitus, anti-diabetic,
Date: 2018
URI: https://ir.uitm.edu.my/id/eprint/84259
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84259

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