Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman

Radman, Ekha Mardziah (2010) Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman. Masters thesis, Universiti Teknologi MARA.

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Abstract

The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against
microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of microwave irradiation to reduce drug release
extent than MG microspheres. In response to microwave, the drug release profiles of 1:1 MG-MG microspheres resembled MC microspheres. The state of polymer-polymer and drug-polymer interaction via 0-H and/or N-H moiety of microspheres was affected by alginate chain flexibility under the influence of microwave. It then governed the drug
release responses of microspheres.

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Item Type: Thesis (Masters)
Creators:
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Radman, Ekha Mardziah
UNSPECIFIED
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Pharmacy
Item ID: 4833
Uncontrolled Keywords: Drugs, Microwave, microspheres
URI: https://ir.uitm.edu.my/id/eprint/4833

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