Radman, Ekha Mardziah
(2010)
Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman.
Masters thesis, Universiti Teknologi MARA.
Abstract
The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against
microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of microwave irradiation to reduce drug release
extent than MG microspheres. In response to microwave, the drug release profiles of 1:1 MG-MG microspheres resembled MC microspheres. The state of polymer-polymer and drug-polymer interaction via 0-H and/or N-H moiety of microspheres was affected by alginate chain flexibility under the influence of microwave. It then governed the drug
release responses of microspheres.
Metadata
Item Type: | Thesis (Masters) |
---|---|
Creators: | Creators Email / ID Num. Radman, Ekha Mardziah UNSPECIFIED |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Divisions: | Universiti Teknologi MARA, Shah Alam > Faculty of Pharmacy |
Keywords: | Drugs, Microwave, microspheres |
Date: | 2010 |
URI: | https://ir.uitm.edu.my/id/eprint/4833 |
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