Characterization and dissolution studies of salicylic acid loaded multi-walled carbon Nanotubes / Mohd Lokman Ibrahim

Ibrahim, Mohd Lokman (2019) Characterization and dissolution studies of salicylic acid loaded multi-walled carbon Nanotubes / Mohd Lokman Ibrahim. Science Letters (ScL), 13 (1). pp. 8-22. ISSN (eISSN) 2682-8626

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Abstract

Multi-walled carbon nanotubes (MWCNTs) have been known as an innovative carrier for drug support and delivery applications. Herein, the modification of MWCNTs was carried out to improve dispersibility and biocompatibility levels. MWCNTs were functionalized by an aqua regia of concentrated nitric acid (HNO3) and sulfuric acid (H2SO4) to produce functionalized MWCNTs (f-MWCNTs). Meanwhile, the salicylic acid was loaded on the f-MWCNTs by sonication technique and the resultant was coded as SA-MWCNTs. Dissolution analysis was carried out in the different medium of simulated body fluid (SBF), simulated gastric fluid (SIF) and simulated gastric fluid (SGF) to evaluate the profile of drug release of SA-MWCNTs. It was found that the release profile of aspirin displayed 2-stage of releases; (1) fast release within 1 to 5-hours followed by (2) sustainable release for up to 12-hours. Thus, showing the compatibility of the f-MWCNTs for salicylic acid controlled released system.

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Item Type: Article
Creators:
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Ibrahim, Mohd Lokman
UNSPECIFIED
Subjects: T Technology > TA Engineering. Civil engineering > Materials of engineering and construction
T Technology > TA Engineering. Civil engineering > Materials of engineering and construction > Nanostructured materials
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Applied Sciences
Journal or Publication Title: Science Letters (ScL)
UiTM Journal Collections: UiTM Journal > Science Letters (ScL)
ISSN: (eISSN) 2682-8626
Volume: 13
Number: 1
Page Range: pp. 8-22
Item ID: 47049
Uncontrolled Keywords: MWCNTs, Functionalization, Salicylic acid, Adsorption, Dissolution
URI: https://ir.uitm.edu.my/id/eprint/47049

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47049

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