Synthesis, characterization and cytotoxic activity of betulinic acid glucosides against human myeloid leukemia and human T-4 lymphoblastoid cell lines / Mohd Tajudin Mohd Ali and Nurhana Faujan

Mohd Ali, Mohd Tajudin and Faujan, Nurhana (2016) Synthesis, characterization and cytotoxic activity of betulinic acid glucosides against human myeloid leukemia and human T-4 lymphoblastoid cell lines / Mohd Tajudin Mohd Ali and Nurhana Faujan. Science Letters (ScL), 10 (1): 5. pp. 14-17. ISSN (eISSN): 2682-8626
Abstract

Glycosylation of betulinic acid with B-D-glucose-pentaacetate was successfully synthesized in the presence of boron trifluoro etherate (BF3.Et2O) in pyridine to give betulinic acid bisglucoside in 92.8% yield. Further treatment of bisglucosides with methanol and sodium metal produced high polarity betulinic acid glucoside with 45% yield. Evaluation of human myeloid leukemia cell (HL60) and human T4-lymphoblastoid cell (CEMSS) activities with both synthesized compounds revealed that both compounds were less potent compared to betulinic acid itself but their water solubility were slightly increase.

Item Details
Item Type: Article
Creators:
Creators
Email / ID Num.
Mohd Ali, Mohd Tajudin
UNSPECIFIED
Faujan, Nurhana
UNSPECIFIED
Subjects: R Medicine > RC Internal Medicine > Specialties of internal medicine
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Applied Sciences
Journal or Publication Title: Science Letters (ScL)
UiTM Journal Collections: UiTM Journals > Science Letters (ScL)
ISSN: (eISSN): 2682-8626
Volume: 10
Number: 1
Page Range: pp. 14-17
Keywords: Anti-leukemia, Betulinic acid, Bisglycoside Glycosylation
Date: June 2016
URI: https://ir.uitm.edu.my/id/eprint/41504
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