Mohd Ali, Mohd Tajudin and Faujan, Nurhana
(2016)
Synthesis, characterization and cytotoxic activity of betulinic acid glucosides against human myeloid leukemia and human T-4 lymphoblastoid cell lines / Mohd Tajudin Mohd Ali and Nurhana Faujan.
Science Letters (ScL), 10 (1): 5.
pp. 14-17.
ISSN (eISSN): 2682-8626
Abstract
Glycosylation of betulinic acid with B-D-glucose-pentaacetate was successfully synthesized in the presence of boron trifluoro etherate (BF3.Et2O) in pyridine to give betulinic acid bisglucoside in 92.8% yield. Further treatment of bisglucosides with methanol and sodium metal produced high polarity betulinic acid glucoside with 45% yield. Evaluation of human myeloid leukemia cell (HL60) and human T4-lymphoblastoid cell (CEMSS) activities with both synthesized compounds revealed that both compounds were less potent compared to betulinic acid itself but their water solubility were slightly increase.
Metadata
| Item Type: | Article |
|---|---|
| Creators: | Creators Email / ID Num. Mohd Ali, Mohd Tajudin UNSPECIFIED Faujan, Nurhana UNSPECIFIED |
| Subjects: | R Medicine > RC Internal Medicine > Specialties of internal medicine |
| Divisions: | Universiti Teknologi MARA, Shah Alam > Faculty of Applied Sciences |
| Journal or Publication Title: | Science Letters (ScL) |
| UiTM Journal Collections: | UiTM Journal > Science Letters (ScL) |
| ISSN: | (eISSN): 2682-8626 |
| Volume: | 10 |
| Number: | 1 |
| Page Range: | pp. 14-17 |
| Keywords: | Anti-leukemia, Betulinic acid, Bisglycoside Glycosylation |
| Date: | June 2016 |
| URI: | https://ir.uitm.edu.my/id/eprint/41504 |
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