The preliminary cytotoxicity study: anti-proliferative activity of aqueous extract of clinacanthus nutans, strobilanther crispa and pereskia bleo on oral squamous carcinoma cells orl-48 / Rahayu Zulkapli and Fathilah Abdul Razak.

Zulkapli, Rahayu and Abdul Razak, Fathilah (2019) The preliminary cytotoxicity study: anti-proliferative activity of aqueous extract of clinacanthus nutans, strobilanther crispa and pereskia bleo on oral squamous carcinoma cells orl-48 / Rahayu Zulkapli and Fathilah Abdul Razak. In: Proceedings of 9th Dental Student’s Scientific Symposium,Malaysia (Malaysia, 2019), 9th – 10th April 2019, Faculty Dentistry, Universiti Teknologi MARA.

Abstract

This in vitro study was carried out to screen the aqueous extracts of selected local plants (clinacanthus nutans, strobilanther crispa and pereskia bleo) known locally to possess anticancer properties for cytotoxic activity. Method: The antiproliferative activity on human oral squamous cell carcinoma, ORL-48 was assessed based on a colorimetric assay using neutral red dye. Result: Clinacanthus nutans exhibited an IC50 of 49.8 ± 0.02 µg/mL on ORL-48 cells, while Strobilanther crispa and Pereskia bleo showed no antiproliferative response. Conclusion: The aqueous extract of clinacanthus nutans, strobilanther crispa and pereskia bleo does not possess anti proliferative activity towards oral squamous carcinoma cells ORL-48.

Metadata

Item Type: Conference or Workshop Item (Paper)
Creators:
Creators
Email / ID Num.
Zulkapli, Rahayu
UNSPECIFIED
Abdul Razak, Fathilah
UNSPECIFIED
Subjects: R Medicine > RK Dentistry > Oral and dental medicine. Pathology. Diseases
R Medicine > RK Dentistry > Prosthetic dentistry. Prosthodontics
Divisions: Universiti Teknologi MARA, Selangor > Sungai Buloh Campus
Event Title: Proceedings of 9th Dental Student’s Scientific Symposium,Malaysia (Malaysia, 2019)
Event Dates: 9th – 10th April 2019
Page Range: pp. 1-2
Keywords: Cancer therapies, oral squamous cell carcinoma (OSCC), plant extracts
Date: 2019
URI: https://ir.uitm.edu.my/id/eprint/30159
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