Status of inflammation among negritos and Malays with Metabolic Syndrome / Noor Mohd Firdaus Othman

Othman, Noor Mohd Firdaus (2019) Status of inflammation among negritos and Malays with Metabolic Syndrome / Noor Mohd Firdaus Othman. Masters thesis, Universiti Teknologi MARA (Kampus Sg. Buloh).

Abstract

Objective: To determine metabolic syndrome components with inflammatory biomarker among Negritos compared with Malays.
Method: 600 subjects (150 Negritos, 450 Malays) were recruited in this cross-sectional study. 127 subjects (21 Negritos, 106 Malays) were diagnosed with MS while 473 were non-MS (129 Negritos, 344 Malays). The groups were matched for age and gender. Serum samples were collected for analysis of biomarkers of inflammation [high-sensitivity C-reactive protein (hsCRP)].
Result: Amongst the Malays and Negritos, MS subjects had higher hsCRP (p<0.05) than their non-MS counterpart. High incidences of low HDL-c levels were observed in Negritos but none was detected among the Malays.
Conclusion: MS is associated with enhanced inflammation, endothelial activation and pro- thrombogenesis. Orang Asli staying in the inlands are predisposed to cardiovascular diseases. The perception of Orang Asli being healthier than the urban people no longer holds. Inherent genetic background may contribute to the increased risk of coronary artery disease.

Metadata

Item Type: Thesis (Masters)
Creators:
Creators
Email / ID Num.
Othman, Noor Mohd Firdaus
2014577661
Contributors:
Contribution
Name
Email / ID Num.
Thesis advisor
Abdul Rahman, Thuhairah Hasrah
UNSPECIFIED
Subjects: R Medicine > RB Pathology > Manifestations of disease
R Medicine > RC Internal Medicine > Specialties of internal medicine > Diseases of the endocrine glands. Clinical endocrinology
R Medicine > RC Internal Medicine > Diabetes Mellitus
Divisions: Universiti Teknologi MARA, Selangor > Sungai Buloh Campus > Faculty of Medicine
Programme: Master of Pathology
Keywords: Metabolic syndrome, Negritos, Inflammation, Malays
Date: 2019
URI: https://ir.uitm.edu.my/id/eprint/29735
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