Carboxymethylcellulose scaffolds for treatment of partial thickness burn wound - the aspects of wound moist regulation, bacterial burden control and tocotrienol therapeutic / Nor Amlizan Ramli

Sodium carboxymethylcellulose (SCMC) is widely used in the design of wound dressing owing to its high water bonding capacity, good compatibility with skin and mucous membrane, biocompatibility and abundant availability at a low cost. This study aims to design drug-free (low (LV), medium (MV) and high molecular weight (HV)) SCMC scaffolds and promote their ability to promote partial thickness burn wound healing via wound moist regulation and microbial burden control. In addition, SCMC scaffolds of distinct wound healing ability is incorporated with γ-tocotrienol as antioxidant therapeutic and has its wound healing property assessed against pure tocopherol and tocotrienol. SCMC scaffolds were prepared by means of solvent evaporation technique and their physicochemical properties namely, in vitro erosion, moisture affinity, morphology, tensile strength, polymer molecular weight and carboxymethyl substitution were investigated against partial thickness burn wound.