Abstract
Tetrahydro-β-carboline (THβC) alkaloids, a varied group of indole-derived chemicals, demonstrate pharmacological actions including anticancer, antibacterial, antioxidant, and neuroactive effects in nature. In this study, 6-methoxy-tetrahydro-β-carboline (6MTHβC) has been synthesized and evaluated for its toxicity against the human neuroblastoma cell line (SK-N-SH) using the MTT assay. The assay was conducted at a concentration of 50 μM of each compound. The findings showed that four compounds exhibited toxicity toward SK-N-SH cells, while eight compounds demonstrated more than 50% cell viability. This study provides fundamental toxicological insights into these compounds and lays the groundwork for pharmacological and potential new treatment possibilities related to neurodegenerative disease.
Metadata
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Creators: | Creators Email / ID Num. Mohamed, Siti Mazleena mazleena@uitm.edu.my Ezzat, Mohammed Oday UNSPECIFIED Mordi, Mohd Nizam UNSPECIFIED |
| Subjects: | L Education > LB Theory and practice of education > Higher Education > Curriculum R Medicine > RC Internal Medicine > Cancer > Research. Experimentation |
| Divisions: | Universiti Teknologi MARA, Perak > Tapah Campus > Faculty of Applied Sciences |
| Journal or Publication Title: | SCIENTIFIC PROJECT COLLOQUIUM (SPC 2025) |
| Event Title: | Final Year Project Colloquium 2025 |
| Event Dates: | 12 July 2025 |
| Page Range: | pp. 20-23 |
| Keywords: | Cytotoxicity, Tetrahydro-β-carboline, Human neuroblastoma cell |
| Date: | October 2025 |
| URI: | https://ir.uitm.edu.my/id/eprint/131411 |
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