Calcium gatekeepers within: turning the tide on breast cancer chemoresistance

Breast cancer remains one of the most common and challenging diseases worldwide. Despite remarkable advances in early detection and treatment, many patients still face relapse, a painful reminder that some tumours have learned to fight back. Why does this happen? The truth is that cancer cells are remarkably adaptive. When exposed to chemotherapy, they do not simply die; they change. They reprogramme their inner systems to withstand treatment, a phenomenon known as chemoresistance.It is one of the biggest obstacles standing between today’s therapies and long-term cures.