The analysis of alpha thalassaemia major and alpha thalassaemia minor based on data DNA analysis at Hospital Raja Perempuan Zainab II, Kelantan

The aim of the present study was to compare the numbers of patient alpha thalassaemia major with the numbers of patient thalassaemia minor. Thalassaemia is an inherited blood disorder due to imbalance the formation polypeptide chain. It was alpha thalassaemia major and alpha thalassaemia minor. Among eighty (80) samples of positive thalassaemia results was taken for this study. The results were collected from data of DNA analysis that taken on July and August as the highest case of the month in 2013. The data obtained composed with results full blood count, full blood picture, Hb analysis and DNA analysis. From the results obtained, it can be concluded that alpha thalassaemia minor is more cases than alpha thalassaemia major. The deletion of one or two alpha genes is alpha thalassaemia minor. But alpha thalassaemia major such as Hb H disease and Hb Bart’s. In the same time, it was develop new knowledge about alpha thalassaemia that DNA analysis is the best selection for investigate this case due the test used is Polymerase chain reaction (PCR).