Development of design advisor tools of upstream processing for biopharmaceutical production: article

Unstructured and structured kinetic model is used in introducing the production of antibody starting from cell growth, substrate uptake until the antibody is produce. Basically, the production of antibody are varies depending on the cell used. Thus, take time in the conformation of the production rate by the experimental data. This research is to develop a design advisor tool that focuses on upstream processing of biopharmaceutical production. The upstream process of monoclonal antibody production will be used as reference model and it is limited to batch processing only. The unstructured model of kinetic equation is used in the growth model. The developed tool should be able to assess the design capacity as well as the economics of the process. MATLAB program was used to produce the command setting as well as the graphical user interface. The design advisor tool was tested and verified through a case study of conceptual design of monoclonal antibody production using SuperPro Designer software. The developed advisor tool was able to predict the progress of cell growth, product formation, and the substrate uptake.