Study on dissolution behaviour of beta Succinic acid in one (1) ethanol solvent using molecular modelling method

Succinic acid (SA) is a potential co-former that commonly used to produce co-crystal likes Carbamazepine-Succinic acid (CBZ-SA) co-crystal. The physicochemical properties of SA are of interest since they control the behavior of crystal in different environment. In this study, the morphology of co-former Succinic acid (SA) was referred to the previous study that have been done while the dissolution behavior of SA in ethanol was tested using dynamic simulation by considering the transport properties of both co-crystal and solvent. The predicted SA morphology shows a hexagonal-like shape with the chosen crystal facet of (1 0 0), (0 2 0), (1 1 1), (3 1 0) and (2 1 2). In this research work, the MD simulation of dissolution of β-succinic acid has been successfully carried out. Two main assessment done by analysis of mean square displacement (MSD) and radial distribution function (RDF). From the analysis, facet (3 1 0) has the highest dissolution coefficient tends to dissolve faster compare to the most morphological important crystalline facet