Slow cooling cocrystallization of ibuprofen and glutaric acid in ethanol and propanol solvent

Cocrystallization is a technique used to improve the physicochemical properties of an active pharmaceutical ingredients (APIs). Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is usually used as pain relieve medicine or to reduce fever that has low solubility limitation in gastrointestinal tract despite its high permeability. The aim of this research project is to investigate the cocrystal formation between ibuprofen and glutaric acid at different ratio in the ethanol and propanol solvent by using slow cooling of cocrystallization technique in order to enhance the solubility of the ibuprofen. The characteristic of the cocrystal was determined by using optical microscopy, differential scanning calorimetry (DSC), powder x-ray diffraction (PXRD) and fourier infrared spectroscopy (FTIR). The result in DSC showed new melting point indicating there was presence of cocrystal