Cytotoxicity study of selected Malaysian honey on chang cell

Honey is a natural sweet substance that produced from honey bees which comes from the nectar of plants, or excretions of living parts of plant. Over time, the collected honey will be ripen and mature in the honey comb and transform into honey (Codex Alimentarus, 2001 ). Honey is considered as multipurpose substance because apart from its usage as a sweetener in food, it also used in nutraceutical and therapeutics products. This is due to the presence of antioxidant in honey namely flavonoids and phenolic acids (Pichichero, Cicconi, Mattei, Muzi, & Canini, 2010). There are many studies on the benefits of honey. Honey able to slow down the proliferation of cancer cells (Pichichero et al., 2010), inhibit cell lysis (Brudzynski & Sjaarda, 2014) and used as antiseptic for substance in wound dressing (Tait & Page, 2009). Although the benefits of honey have been highlighted by many researchers, the toxicity of the honey is not brightly explained. This is because, high toxicity of honey will affect the cell to undergo necrosis· and cause the cell to stop growing and dividing which can lead to cell apoptosis.