The expression of bini gene in blood of alzheimer's disease patients

Alzheimer's disease is a neurodegenerative disease which it shows slowly progressive loss of cognitive functions and would lead to dementia and death. The pathogenesis involves amyloid hypothesis and oxidative stress pathway. For amyloid hypothesis, there is an aggregation of B amyloid protein in the extracellular area of cortical region of brain. As for oxidative pathway, there is presence of neurofibrillary tangles formed inside the neurons. There are many genes showing expression in AD. In this study, BINI gene is used. The expression level of BINI gene in AD subjects is higher than the expression level of BIN I gene in healthy subjects. The fold changes of the BIN I gene in AD show that it express 8 times more than the BIN I gene in healthy subjects. The finding of blood based biomarker to detect AD in early stages would reduce the burden of care taker and reduce mortality rate of AD thus would lead to increase the quality of life of AD patients.