Wound healing properties of marine endophytic fungi extracts on sprague-dawley rats / Aqilah Hasanah Mohd Amin

Bum wound that is mainly caused by heat can cause damage to the skin if it happens to be in contact with. Second degree bum wounds will cause damage to the papillary and reticular dermis. Previous study had shown that the marine endophytic fungi have a potent antimicrobial and anti-cancer properties. However, some research were conducted on the extracts and their potential in wound bum wound healing. Thus, in this study the potential of three marine endophytic fungi extracts on second degree bum wound healing was investigated. Marine endophytic fungi were isolated from the three different species of seaweed namely Gracilaria coronopifolia (CN), Graci/aria arucuata Zanardini (MV) and Acanthophora spicifera (EDI). Circular second degree bum wounds were created on the dorsal region of rats and treated with positive control (silver sulphadiazine, SSD), negative control (Tween 20) and the marine endophytic fungi methanol extracts (CN, MV and EDI). The fastest rate of healing was observed for the CN extract (80.2±2.0 I%) as compared to other groups. This finding represent the first reported investigation of 2"d degree bum wound healing marine endophytic fungi extracts. Marine endophytic fungi extracts have a potential as an alternative for bum wound healing agent.