Preparation of drug carrier from glycoside and polymer: drug release study / Muhammad Amir Bukhari Adenan

Nano-sized vesicles formed from self-assembly glycoside were produced by using two type of different glycoside which is Glucoside Palm Kernel Oil (GPKO) and Galactoside Palm Kernel Oil (GalPKO) with the addition of Polyethylene Glycol (PEG) 12 to optimized drug loading and releasing property and Cholesterol to form a stable vesicle. Besides, dicetyl phosphate (DCP) was added into the vesicle formulation because to induce negative charge and minimize the aggregation between neutral uncharged molecules. The sample is then analyzed for their vesicle characterization to check on their size, polydispersity index (PDI) and surface zeta potential. The main objective is to study the release of drug encapsulated in the vesicle and it is accomplished by using fluorescence spectrophotometer to get the release concentration per unit time.