Microbial transformation of andrographolide and medroxyprogesterone / Nur Asma Dalila Abdul Razak

Abdul Razak, Nur Asma Dalila (2015) Microbial transformation of andrographolide and medroxyprogesterone / Nur Asma Dalila Abdul Razak. Degree thesis, Universiti Teknologi MARA (Kampus Puncak Alam).

Abstract

Microbial transformation has been known for a long time.The biotransformation allows the compound to be modified without the use of any chemical reagent and biotransformation act as a green chemistry. In this study, andrographolide and medroxyprogesterone have been used as a substrate that undergo fermentation with selected endophytes which are Aspergillus niger, Beauveria bassiana , R3-2SP17 , R3-3SP2, R3-3SP30, SC 24J, Cunninghamella elegans , Verticillium lecanii , SSW and Absidia coerulea . Method involved are media preparation, inoculation of fungi, feeding of substrate, incubation for 4 days and 8 days and extraction with ethyl acetate. The extracts were analyzed by HPLC to identify any biotransformation products.

Metadata

Item Type:	Thesis (Degree)
Creators:	Creators Email / ID Num. Abdul Razak, Nur Asma Dalila UNSPECIFIED
Contributors:	Contribution Name Email / ID Num. Thesis advisor Sultan, Sadia UNSPECIFIED
Subjects:	Q Science > QR Microbiology > Microbial ecology Q Science > QR Microbiology > Cultures and culture media. Culture technique. Q Science > QR Microbiology > Bacteria
Divisions:	Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Pharmacy
Programme:	Bachelor of Pharmacy
Keywords:	Microbial transformation, andrographolide, medroxyprogesterone
Date:	2015
URI:	https://ir.uitm.edu.my/id/eprint/116895