Molecular docking of potential inhibitors of curcumin and its derivatives towards PPAR gamma / Nurdina Adlina Mohd Suzaimi

Diabetes is a disease caused by high sugar intake. It is happening when someone's body is not reacting appropriately to the effects of insulin that function to regulate the blood sugar level by transferring it into the cells. In the article by Dr. Saiful Bahari Kassim, who is the Consultant Endocrinologist and Head of the Department of Endocrinology suggests that healthy lifestyle to control diabetes in someone's condition [1]. However, there are still needs for prescribed medicine to be consumed by diabetes-infected persons. Turmeric has been used in traditional medicine, which is traditional Chinese medicine that can be used for diabetes [2]. Recent research has shown that an active component of turmeric, curcumin, has anti-inflammatory, anti-cancer and antioxidant properties that have been proven to benefit in preventing and treating various diseases including cancer, autoimmune, cardiovascular, neurological and diabetes disease [3]. Nowadays, computational techniques are widely used for accelerating drug discovery and reducing the cost-effectiveness of laboratory screening experiments. In this study, molecular docking of three phytochemicals from turmeric was carried out against non- thiazolidinediones (nTZDs). The results revealed that some of the phytochemicals showed a better dock score compared to the curcumin. Based on the score, it is suggested that these compounds can be further studied for potential drugs against diabetes.