Molecular dynamic simulations: prediction of dissolution of succinic acid crystal (form B) in ethanol solution / Mohammad Ammar Rajab

Pharmaceutical industry nowadays have undergoes many advancement ,due to rapid growth of technology. Low solubility drug has been one of main concern inside this industry. Several ways to overcome this is by introduction current drug to new additive called co former which generally regarded as safe by FDA. This co former act as additive that enhance bioavailability such as dissolution and solubility without changing the drug function. In this case we are studying on Succinic Acid (form B) crystal which possibly be one of the best co former for Carbamazepine (CBZ) Drug. The aim of this experiment is to predict the morphology of succinic acid (form B) with the presence of ethanol solvent and also to assess the dissolution behaviour of succinic acid (form P) inside ethanol solvent by using molecular dynamic approach(MD) that mainly utilizing Material Studio Software. The Succinic Acid (form B ) structural data retrieve Cambridge Structural Database (CSD).