Gelatine carrier for Metformin drug

During the past few decades there has been an increasing interest in the development of biodegradable micro/nanoparticles as drug delivery devices. Previous studies have reported that some existing additives are expensive and have poor degradability. The use of edible-based biodegradable additive remains attractive because of their abundance in nature and costeffective. Biodegradable micro and nano-particulate additive is proposed. Selected local additiveproduced locally is incorporated with Metformin drug. Characterization, physical study and biological study was attempted, such as determination, morphological and rheological test, drug loading capabilities, biodegradation, toxicity and in vitro studies. The focus of the study is to create local biodegradable micro- and nano-sized particulate additive with Metformin loading formulation theory for drug delivery system. Apart from that, formulation theory created purposely aims to support the Malaysia's NKEA in healthcare so that local generic manufacturing for export can be increases.