Antibacterial activity of endophytic streptomyces spp. isolated from medicinal plants of dental importance / Nur Aisya Syaheera Rohizan ... [et al.]

Rohizan, Nur Aisya Syaheera and Mohamad Rasidi, Mohamad Luqman Hakim and Mohd Sarmin, Nurul ‘Izzah and Said Ghulam Khan, Hasnah Begum (2025) Antibacterial activity of endophytic streptomyces spp. isolated from medicinal plants of dental importance / Nur Aisya Syaheera Rohizan ... [et al.]. Compendium of Oral Science (COS), 12 (1). pp. 96-109. ISSN 2489-1102; 2637-0611

Abstract

Wide variations of plant species in Malaysia provide suitable hosts for the isolation of endophytic streptomycetes, which can be potential sources of bioactive compounds with therapeutic applications in dentistry.
Objectives: This study’s objectives were to isolate endophytic streptomycetes from medicinal plants and to evaluate their antibacterial activity against Streptococcus mutans, a key pathogen responsible for dental caries.
Methods: Endophytic streptomycetes were isolated from seven fresh plants: Mauritius papeda (Kaffir lime), Cosmos caudatus (Ulam Raja plant), Lawsonia inermis (Henna plant), Piper sarmentosum (Kadok), Kaempferia galanga (Cekur plant), Ziziphus mauritiana (Bidara plant), and Psidium guajava (Guava plant), using a surface-sterilization method. Different plant parts were placed on five isolation media, namely Water Agar, International Streptomyces Project (ISP) 2, ISP 4, ISP 5, and Tap Water Yeast Agar, and incubated at 37°C for up to one month. Isolates were identified by morphological characteristics and tested for antimicrobial activities through a cross-streak assay.
Results: A total of 38 endophytes were successfully isolated, with 19 identified as streptomycetes. Specifically, seven, two, five, and three endophytes were isolated from stem, root, leaf, and fruit, respectively. Three endophytic streptomycetes exhibited antagonistic activity against S. mutans.

Metadata

Item Type: Article
Creators:
Creators
Email / ID Num.
Rohizan, Nur Aisya Syaheera
UNSPECIFIED
Mohamad Rasidi, Mohamad Luqman Hakim
UNSPECIFIED
Mohd Sarmin, Nurul ‘Izzah
izzahsarmin@uitm.edu.my
Said Ghulam Khan, Hasnah Begum
UNSPECIFIED
Subjects: R Medicine > RK Dentistry
R Medicine > RK Dentistry > Oral and dental medicine. Pathology. Diseases
Divisions: Universiti Teknologi MARA, Selangor > Sungai Buloh Campus > Faculty of Dentistry
Journal or Publication Title: Compendium of Oral Science (COS)
UiTM Journal Collections: UiTM Journals > Compendium of Oral Science (CORALS) (COS)
ISSN: 2489-1102; 2637-0611
Volume: 12
Number: 1
Page Range: pp. 96-109
Keywords: endophytes, streptomycete, medicinal plants, antibacterial
Date: March 2025
URI: https://ir.uitm.edu.my/id/eprint/114248
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