Ethnicity and habits in p53 gene mutation in oral squamous cell carcinoma / Fatimah Suriati Sulaiman, Khor Goot Heah and Jamil Ahsan Kazi

Sulaiman, Fatimah Suriati and Khor, Goot Heah and Kazi, Jamil Ahsan (2025) Ethnicity and habits in p53 gene mutation in oral squamous cell carcinoma / Fatimah Suriati Sulaiman, Khor Goot Heah and Jamil Ahsan Kazi. Compendium of Oral Science (COS), 12 (1). pp. 53-64. ISSN 2489-1102; 2637-0611

Abstract

Objectives: Our previous study demonstrated that 31% (n=58/18) of OSCC patients have p53 gene mutation. In this study, we investigate the relationship of ethnicity and habit to p53 gene mutation of oral squamous cell carcinoma (OSCC).
Methods: The present study used Multiplex Ligation-dependent Probe Amplification (MLPA) to examine p53 gene mutation from exon 1 to 11. DNA specimens from 58 OSCC patients and 10 healthy people (controls) were used in this study. Our results demonstrated that 31% (n=58/18) of OSCC patients have p53 gene mutation. Among them 56% (n=10/18) of mutation occurred in exon 3, followed by exon 4 which was 50% (n=9/18).
Result: The Malay, Indian, and Chinese ethnic groups each accounted for 28% of OSCC patients with p53 gene mutations. 56% of the individuals had a habit of smoking, drinking alcohol, or chewing betel quid.56% of the individuals had a habit of smoking, drinking alcohol, or chewing betel quid. Sixty percent (n=6) of Chinese and Malay patients have mutations in almost all exons, while Indian patients primarily have mutations in exon 4.
Conclusion: Our current study suggests that further investigation is needed to understand the relationship between ethnicity, habits, and their interaction with genetic and epigenetic modifiers in exon-specific p53 mutations

Metadata

Item Type: Article
Creators:
Creators
Email / ID Num.
Sulaiman, Fatimah Suriati
UNSPECIFIED
Khor, Goot Heah
UNSPECIFIED
Kazi, Jamil Ahsan
kazi@uitm.edu.my
Subjects: R Medicine > RK Dentistry > Oral and dental medicine. Pathology. Diseases
R Medicine > RK Dentistry > Preventive dentistry
Divisions: Universiti Teknologi MARA, Selangor > Sungai Buloh Campus > Faculty of Dentistry
Journal or Publication Title: Compendium of Oral Science (COS)
UiTM Journal Collections: UiTM Journals > Compendium of Oral Science (CORALS) (COS)
ISSN: 2489-1102; 2637-0611
Volume: 12
Number: 1
Page Range: pp. 53-64
Keywords: Oral squamous cell carcinoma, p53 gene mutations, Exon, MLPA, Habit, Ethnicity
Date: March 2025
URI: https://ir.uitm.edu.my/id/eprint/114239
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