Abstract
Objectives: Our previous study demonstrated that 31% (n=58/18) of OSCC patients have p53 gene mutation. In this study, we investigate the relationship of ethnicity and habit to p53 gene mutation of oral squamous cell carcinoma (OSCC).
Methods: The present study used Multiplex Ligation-dependent Probe Amplification (MLPA) to examine p53 gene mutation from exon 1 to 11. DNA specimens from 58 OSCC patients and 10 healthy people (controls) were used in this study. Our results demonstrated that 31% (n=58/18) of OSCC patients have p53 gene mutation. Among them 56% (n=10/18) of mutation occurred in exon 3, followed by exon 4 which was 50% (n=9/18).
Result: The Malay, Indian, and Chinese ethnic groups each accounted for 28% of OSCC patients with p53 gene mutations. 56% of the individuals had a habit of smoking, drinking alcohol, or chewing betel quid.56% of the individuals had a habit of smoking, drinking alcohol, or chewing betel quid. Sixty percent (n=6) of Chinese and Malay patients have mutations in almost all exons, while Indian patients primarily have mutations in exon 4.
Conclusion: Our current study suggests that further investigation is needed to understand the relationship between ethnicity, habits, and their interaction with genetic and epigenetic modifiers in exon-specific p53 mutations
Metadata
Item Type: | Article |
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Creators: | Creators Email / ID Num. Sulaiman, Fatimah Suriati UNSPECIFIED Khor, Goot Heah UNSPECIFIED Kazi, Jamil Ahsan kazi@uitm.edu.my |
Subjects: | R Medicine > RK Dentistry > Oral and dental medicine. Pathology. Diseases R Medicine > RK Dentistry > Preventive dentistry |
Divisions: | Universiti Teknologi MARA, Selangor > Sungai Buloh Campus > Faculty of Dentistry |
Journal or Publication Title: | Compendium of Oral Science (COS) |
UiTM Journal Collections: | UiTM Journals > Compendium of Oral Science (CORALS) (COS) |
ISSN: | 2489-1102; 2637-0611 |
Volume: | 12 |
Number: | 1 |
Page Range: | pp. 53-64 |
Keywords: | Oral squamous cell carcinoma, p53 gene mutations, Exon, MLPA, Habit, Ethnicity |
Date: | March 2025 |
URI: | https://ir.uitm.edu.my/id/eprint/114239 |