Preparation and evaluation of nifedipine nanoemulgel / Felicia Pukan Daniel

Nanoemulsion typically is having droplet size ranging from 20 - 200nm in diameter. With these nano-scaled sized droplets, it could demonstrate high stability and assists in better permeability across membrane. Utilization of nanotechnology in nifedipine delivery topically intends for the treatment of anal fissure and wound healing. The present study aim to formulate a topical nifedipine nanoemulsion incorporated with Carbopol to produce nanoemulgel. The optimum 2% nifedipine nanoemulsion formulation was consisted of 60% avocado oil, 16% of sucrose laureate and 24% glycerol which produce nano-scaled size particles. Highest percentage of oil component was selected to ensure complete dissolution of nifedipine. Addition of Carbopol helps in enhancing the physical characterization of the formulation which includes the texture, rheology and stability. The influence of Carbopol percentage to these physical characterizations of the formulation was determined. Based on the study, nanoemulgel with 0.75% Carbopol demonstrated the best formulation which could be used in optimizing topical formulation of nifedipine to meet patient compliance.