Interaction between methanolic extract of hibiscus rosa-sinensis leaves and glibenclamide in streptozotocin induced diabetic rats / Nur Shahira Rohani

The interaction between drug-herb interaction may cause synergistic or antagonist effect in the treatment of disease. The present study was conducted to determine the interaction between glibenclamide, a sulfonylureas group of antidiabetic drugs and Hibiscus rosa-sinensis leaves methanol extract, an herbal that has hypoglycemic effect. The effect in lowering of blood glucose levels and the changes in histological study of pancreas tissues were evaluated in the streptozotocin induced diabetic rats. Glibenclamide was administered orally at the dose of 0.5 mg/kg and Hibiscus rosa­ sinensis leaves methanol extract was given at the dose of 125 mg/kg orally. Both glibenclamide and Hibiscus rosa-sinensis leaves methanol extract showed the hypoglycemic effect. The combination of glibenclamide together with Hibiscus rosa­ sinensis leaves methanol extract were indicated greater reduction in the blood glucose levels and increase in the number of pancreatic beta cells instead of using treatment alone. It is concluded that Hibiscus rosa-sinensis leaves methanol extract shows synergistic effect when used together with glibenclamide in reducing blood glucose levels and increasing the number of pancreatic beta cells.