PLGA-based nanoparticles for intranasal drug delivery to brain for alleviating alzheimer's disease / Nur Ermalina Jadi @ Mohd Faiz

Poly (lactic-co-glycolide) (PLGA) is a good polymer and usually is preferable to be loaded with drug agent due to its biodegradability and biocompatibility properties. In this study, Memantine Hydrochloride (MEM) is used, loaded in the novel of PLGA-based nanoparticles for intranasal drug delivery to the brain for alleviating Alzheimer's disease. Nanoparticles are preferred because of its smaller size, thus easier to cross blood brain barrier (BBB). This research deals with PLGA and MEM, in which the main focus is to obtain high drug entrapment efficiency and percentage yield of the PLGA-based nanoparticles loaded with MEM that can be obtained through a number of systemic processes. The purposes of this study are to formulate and characterize the nanoparticles based on Particle Size Analysis, Fourier Transform Infrared (FTIR) Spectroscopy, Zeta Potential Analysis of PLGA Nanoparticles, Differential Scanning Calorimetry (DSC) Study and Scanning Electron Microscopy (SEM) for its morphology. These processes will show the characterizations of nanoparticles and also tell us the best condition of nanoparticles with MEM that can penetrate BBB in the brain via intranasal drug delivery.