Simvastatin solubility in ternary system containing β­-cyclodextrin and HPMC: phase solubility and in vitro dissolution study / Atiqah Mokhtar

Drug solubility plays an important role on influencing the dissolution rate and bioavailability of a drug. On this matter, Simvastatin (SV) exhibits a low solubility but high gastrointestinal permeability. Many studies had been conducted to increase the solubility of SV. This study was conducted to increase the solubility of SV by ternary system of SV with P-cyclodextrin (PCDT) and hydroxypropylmethylcellulose(HPMC). The system was prepared by physical mixing method. In the study series of SV-PCDT-HPMC ratio were synthesized prior to the objectives. The objectives of this study were to investigate the phase solubility study of SV-PCDT and SV-PCDT-HPMC as well as the dissolution rate of optimum formulation of SV-PCDT-HPMC. The in vitro dissolution study was accomplished by using USP-II apparatus. Results show that, ternary system can increase the SV solubility up to some extent. Based on the results, the occurring of physical adsorption arising from the system during physical mixing. This statement is strengthened by solid state characterization performed on the system.