Anticancer activity of methanol extract of micromelum pubescens leaves / Muhammad Izzat Masto

Liver cancer is among the common cancer that contribute to mortality in the world particularly in developing countries. Several factors have been documented to be the etiologies of this cancer. Current treatments for cancer are not give significant success in reverting the disease and researchers continuously put efforts in finding way to improve the treatments. Recently, plant is likely has attracting interest from many researchers to make it as an alternative source in finding the better cancer treatment. Micmomelum pubescens is an attractive plant that can be found in South­ East of Asia country like Malaysia and Sri Lanka which come from a family Rutaceae and genus Micromelum. The principle of this study was to investigate the anticancer properties of species Micromelum pubescens on liver cancer cell lines in vitro. Cell viability study was conducted with MTT assay to see the trend in cell viability with the treatment of methanol extracts of the plant. This is the first study to provide data cytotoxicity of Micromelum pubescens on cancer cells. The extract of Micromelum pubescens leaves was shown to decrease the cell viability of liver cancer cells HepG2, without toxicity in Chang normal cells. ICso of extract on HepG2 cells was 1172.8005 ± 270.99 µg/ml. Micromelum pubescens can be assumed safe for the medicinal purposes. Further studies are needed for other pharmacological or toxicological properties that such extract might have.