Ternary solid dispersion of simvastatin, B-cyclodextrin and HPMC: solid state characterization / Nur Hidayah Besar @ Nik

Besar @ Nik, Nur Hidayah (2014) Ternary solid dispersion of simvastatin, B-cyclodextrin and HPMC: solid state characterization / Nur Hidayah Besar @ Nik. Degree thesis, Universiti Teknologi MARA (Kampus Puncak Alam).

Abstract

Simvastatin (SV) is a drug with poor solubility. Its solubility can be enhanced by incorporating the suitable excipients. In this study, the excipients used were hydroxypropyl methylcellulose (HPMC) polymer matrix and P-cyclodextrin (P­ CD). The technique used was solid dispersion. In equilibrium solubility study, different concentration of SV, HPMC and P-CD are used to make 13 samples consisting of binary and ternary system. Then, the solid state characteristics of the samples in these systems were characterized by using differential scanning calorimetry (DSC), x-ray diffraction (XRD), fourier transformed infrared spectroscopic (FTIR) and thermal gravimetric analysis (TGA). The comparison of solid state characteristics of pure material, SV is made by comparing it with the samples in binary and ternary system.

Metadata

Item Type: Thesis (Degree)
Creators:
Creators
Email / ID Num.
Besar @ Nik, Nur Hidayah
UNSPECIFIED
Contributors:
Contribution
Name
Email / ID Num.
Thesis advisor
Meor Mohd Affandi, Meor Mohd Redzuan
UNSPECIFIED
Subjects: R Medicine > RS Pharmacy and materia medica > Pharmacopoeias
Divisions: Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Pharmacy
Programme: Bachelor of Pharmacy
Keywords: simvastatin (SV), drug, hydroxypropyl methylcellulose (HPMC)
Date: 2014
URI: https://ir.uitm.edu.my/id/eprint/111732
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