Abstract
Simvastatin (SV) is a drug with poor solubility. Its solubility can be enhanced by incorporating the suitable excipients. In this study, the excipients used were hydroxypropyl methylcellulose (HPMC) polymer matrix and P-cyclodextrin (P CD). The technique used was solid dispersion. In equilibrium solubility study, different concentration of SV, HPMC and P-CD are used to make 13 samples consisting of binary and ternary system. Then, the solid state characteristics of the samples in these systems were characterized by using differential scanning calorimetry (DSC), x-ray diffraction (XRD), fourier transformed infrared spectroscopic (FTIR) and thermal gravimetric analysis (TGA). The comparison of solid state characteristics of pure material, SV is made by comparing it with the samples in binary and ternary system.
Metadata
Item Type: | Thesis (Degree) |
---|---|
Creators: | Creators Email / ID Num. Besar @ Nik, Nur Hidayah UNSPECIFIED |
Contributors: | Contribution Name Email / ID Num. Thesis advisor Meor Mohd Affandi, Meor Mohd Redzuan UNSPECIFIED |
Subjects: | R Medicine > RS Pharmacy and materia medica > Pharmacopoeias |
Divisions: | Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Pharmacy |
Programme: | Bachelor of Pharmacy |
Keywords: | simvastatin (SV), drug, hydroxypropyl methylcellulose (HPMC) |
Date: | 2014 |
URI: | https://ir.uitm.edu.my/id/eprint/111732 |
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